Materials Science Research Articles

Synthesis Strategies, Preparation Methods, and Applications of Chiral Metal-Organic Frameworks.

Chiral metal-organic framework (CMOFs) is a kind of material with great application value in recent years. Formed by the coordination of metal ions or metal clusters with organic ligands. It is widely used in chemistry, biology, medicine and materials science because of its ordered and adjustable pores, multi-dimensional network structure, large specific surface area and excellent adsorption properties. In this paper, the synthesis strategies and preparation methods of chiral metal-organic frameworks are reviewed. In addition, the applications of chiral metal-organic framework materials in enantiomer recognition and separation, circularly polarized luminescence and asymmetric catalysis are systematically summarized. Finally, the challenges and prospects of the development of chiral metal-organic frame materials are analyzed in detail.

Higher‐order Behaviours in Bio‐inspired Materials

Bio‐inspired approaches in materials science and systems chemistry are yielding a variety of stimuli‐responsive and dynamic materials that are gradually changing our everyday life. However, the ability to chemically program these materials to exhibit macroscopic higher‐order behaviours such as self‐assembly, contractility, swarming, taxis, chemical communication, or predator‐prey dynamics remains an ongoing challenge. While still in its infancy, the successful fabrication of bio‐inspired materials displaying higher‐order behaviours not only will help bridging the gap between living and non‐living matter, but it will also contribute to the development of advanced materials for potential applications ranging from tissue engineering and biotechnology, to soft robotics and regenerative medicine. Our Mini‐Review will systematically discuss the higher‐order behaviours developed thus far in bio‐inspired systems, namely (i) polymer networks (ii) microbots, (iii) protocells, and (iv) prototissues. For each system it will provide key examples and highlight how the emergent behaviour could be chemically programmed.

Plasmon-emitter coupling in cytosine-rich hairpin DNA-templated silver nanoclusters: Thermal reversibility, white light emission, and dynamics inside live cells.

Bio-templated luminescent noble metal nanoclusters (NCs) have attracted great attention for their intriguing physicochemical properties. Continuous efforts are being made to prepare NCs with high fluorescence quantum yield (QY), good biocompatibility, and tunable emission properties for their widespread practical applications as new-generation environment-friendly photoluminescent materials in materials chemistry and biological systems. Herein, we explored the unique photophysical properties of silver nanoclusters (AgNCs) templated by cytosine-rich customized hairpin DNA. Our results indicate that a 36-nucleotide containing hairpin DNA with 20 cytosine (C20) in the loop can encapsulate photostable red-emitting AgNCs with an absolute QY of ∼24%. The luminescent properties in these DNA-templated AgNCs were found to be linked to the coupling between the surface plasmon and the emitter. These AgNCs exhibited excellent thermal sensitivity and were employed to produce high-quality white light emission with an impressive color rendering index of 90 in the presence of dansyl chloride. In addition, the as-prepared luminescent AgNCs possessing excellent biocompatibility can effectively mark the nuclear region of HeLa cells and can be employed as a luminescent probe to monitor the cellular dynamics at a single molecular resolution.

Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials

Targeted therapy represents a real opportunity to improve the health and lives of patients. Developments in this field are confirmed by the fact that the global market for drug carriers was worth nearly $40 million in 2022. For this reason, materials engineering and the development of new drug carrier compositions for targeted therapy has become a key area of research in pharmaceutical drug delivery in recent years. Ceramics, polymers, and metals, as well as composites, are of great interest, as when they are appropriately processed or combined with each other, it is possible to obtain biomaterials for hard tissues, soft tissues, and skin applications. After appropriate modification, these materials can release the drug directly at the site requiring a therapeutic effect. This brief literature review characterizes routes of drug delivery into the body and discusses biomaterials from different groups, options for their modification with clindamycin, an antibiotic used for infections caused by aerobic and anaerobic Gram-positive bacteria, and different methods for the final processing of carriers. Examples of coating materials for skin wound healing, acne therapy, and bone tissue fillers are given. Furthermore, the reasons why the use of antibiotic therapy is crucial for a smooth and successful recovery and the risks of bacterial infections are explained. It was demonstrated that there is no single proven delivery scheme, and that the drug can be successfully released from different carriers depending on the destination.

Multifunctional Phototransistor Based on Double Van der Waals Heterojunction with Reversed Band Edge Bending

AbstractDouble van der Waals heterojunctions (vdWHs) based on 2D materials showcase multifunctional properties, including anti‐ambipolar behavior and polarization‐sensitive photodetection capabilities, providing a new degree of freedom for the development of next‐generation integrated electronics and optoelectronics. Herein, this work reports an anti‐ambipolar transistor with high polarized photosensitivity based on MoS2/Ta2NiS5/WSe2 double vdWH with back‐to‐back type‐I band alignment. It demonstrates a noticeable negative differential transconductance with an ultrahigh peak‐to‐valley ratio of 4.3 × 104 and a bidirectional transconductance variation from 41.6 to −17.5 nS when VD = 2 V. It is ascribed to the effective gate‐modulation of the reversed band edge bending at the double vdWH interfaces. Additionally, the structure benefits from a photogating effect and the anisotropic Ta2NiS5 interlayer, achieving a peak responsivity of 120.58 A W−1 and a decent specific detectivity of 2.65 × 1012 Jones at VD = 2 V and Vg = 5 V and exhibiting an exceptional photocurrent anisotropic ratio of 15.31 via the photovoltaic effect under 635 nm light. These findings not only expand the potential applications of the advanced 2D Ta2NiS5 material but also offer valuable insights for the development of multifunctional optoelectronic devices leveraging 2D double vdWHs.

3D printing vs traditional workflow for the fabrication of mandibular implant overdentures: study protocol for a mixed-methods cross-over RCT

Abstract Background Complete tooth loss is a significant global oral health issue, particularly impacting older individuals with lower socioeconomic status. Computer-assisted technologies enhance oral healthcare access by the elderly. Despite promising in vitro reports on digital denture materials, evidence from randomized clinical trials (RCTs) is lacking to verify their performance. This cross-over RCT will investigate whether 3D-printed implant-retained mandibular overdentures (IMO) are more satisfactory for edentulous seniors than those made through traditional methods. Methods/design We will recruit 26 completely edentulous participants (any sex/gender) based on the following eligibility criteria: age ≥ 60 years, no tooth extraction in the past 12 months, two implants in the lower jaw, and need for new dentures in both jaws. Each participant will receive two denture pairs, either manufactured by 3D printing or traditionally, to be worn in a random order. A timeline of 3 months with each denture pair will be considered for outcome assessment (total: 6 months). Patient satisfaction with dentures will be measured by the McGill Denture Satisfaction Questionnaire. We will evaluate other patient-reported outcomes (including oral health-related quality of life) as well as clinician-assessed quality and cost. At the end of the trial, participants will choose which denture pair they wish to keep and interviewed about their experiences with the 3D-printed IMO. The quantitative and qualitative data will be incorporated through an explanatory mixed-methods strategy. A final quantitative assessment will happen after 12 months with the preferred IMO to assess the long-term performance and maintenance needs. Discussion This mixed-methods RCT will explore patient experiences with 3D-printed IMOs, aiming to assess the potential for altering clinical practice and dental public health policies. Our results will inform policies by showing whether 3D printing offers comparable outcomes at lower costs, facilitating greater access to oral care for the elderly. Trial registration ClinicalTrials.gov, NCT06155630, Registered on 04 December 2023. https://classic.clinicaltrials.gov/ct2/show/NCT06155630

Molecular-Scale Visualization of Steric Effects of Ligand Binding to Reconstructed Au(111) Surfaces.

Direct imaging of single molecules at nanostructured interfaces is a grand challenge with potential to enable new, precise material architectures and technologies. Of particular interest are the structural morphology and spectroscopic signatures of the adsorbed molecule, where modern probes are only now being developed with the necessary spatial and energetic resolution to provide detailed information at the molecule-surface interface. Here, we directly characterize the adsorption of individual m-terphenyl isocyanide ligands on a reconstructed Au(111) surface through scanning tunneling microscopy and inelastic electron tunneling spectroscopy. The site-dependent steric pressure of the various surface features alters the vibrational fingerprints of the m-terphenyl isocyanides, which are characterized with single-molecule precision through joint experimental and theoretical approaches. This study provides molecular-level insights into the steric-pressure-enabled surface binding selectivity as well as its effect on the chemical properties of individual surface-binding ligands.

PDF-5+: a comprehensive powder diffraction file™ for materials characterization

For more than 80 years, the scientific community has extensively used International Centre for Diffraction Data's (ICDD®) Powder Diffraction File (PDF®) for material characterization, including powder X-ray diffraction analysis. Historically, PDF was made available for two major material types: one for inorganic analysis and the other for organic analysis. In the early years of the PDF, this two-material approach was implemented due to limited computer capabilities. With Release 2024, ICDD provides a comprehensive database consisting of the entire PDF in one database called PDF-5+, comprised of more than one million entries (1,061,898). The PDF-5+ with a relational database (RDB) construct houses extensive chemical, physical, bibliographic, and crystallographic data, including atomic coordinates and raw data, enabling qualitative and quantitative phase analysis. This wealth of information in one database is advantageous for phase identification, materials characterization, and several data mining applications in materials science. A database of this size needs rigorous data curation and structural and chemical classifications to optimize pattern search/match and characterization methods. Each entry in the PDF has an editorially assigned quality mark. An editorial comment will describe the reason if an entry does not meet the top-quality mark. The editorial processes of ICDD's quality management system are unique in that they are ISO 9001:2015 certified. Among several classifications implemented in PDF-5+, subfiles (such as Bioactive, Pharmaceuticals, Minerals, etc.) directly impact the search/match in minimizing false positives. Scientists with specific field expertise continuously review these subfiles to maintain their quality. This paper describes the features of PDF with an emphasis on the newly released PDF-5+.

Endohedral Fullerenes: From Exotic Chemical Bonding to Molecular Circuits

Since their discovery, fullerenes represent a fascina­ting type of molecule with many unusual properties. One of these is the existence of a cavity into which other atoms and molecules can be enclosed to form the so-called endohedral fullerenes. In terms of fundamental research, endohedral fullerenes provide a platform for studying exotic chemical bonds between atoms enclosed inside the fullerene cage. At the same time, endohedral fullerenes also find practical applications, for example in solar cells, material science, electronics and molecular electronics. In this article, we review the research on exotic bonds in fullerenes and the use of fullerenes as molecular components.

Numerical Study of a Latent Heat Storage System’s Performance as a Function of the Phase Change Material’s Thermal Conductivity

The thermal conductivities of most commonly used phase change materials (PCMs) are typically fairly low (in the range of 0.2 to 0.4 W/m·K) and are an important consideration when designing latent heat energy storage systems (LHESSs). Because of that, material scientists have been asking the following question: “by how much does the thermal conductivity of a PCM needs to be increased to positively impact the design and performance of a LHESS?” The answer to this question is not straightforward as the performance of a LHESS depends on the PCM’s thermal conductivity, other PCM thermophysical properties, the type of heat exchange system geometry used, the mode of operation, and the targeted power/energy storage of the LHESS. This paper presents work related to this question through a numerical study based on a simplified 2D model of an experimental setup studied previously in the authors’ laboratory. A model created in COMSOL Multiphysics, based on conduction and accounting for the solid-liquid phase change process, was initially validated against experimental results and then used to study the impact of the PCM’s thermal conductivity (dodecanoic acid) on the discharging power of the LHESS. The results show that even increasing the thermal conductivity of the PCM by a factor of 50 only leads to a maximum instantaneous power increase by a factor of 2 or 3 depending on the LHESS configurations.

Syngas Production from CO2 and H2O via Solid-Oxide Electrolyzer Cells: Fundamentals, Materials, Degradation, Operating Conditions, and Applications.

Highly efficient coelectrolysis of CO2/H2O into syngas (a mixture of CO/H2), and subsequent syngas conversion to fuels and value-added chemicals, is one of the most promising alternatives to reach the corner of zero carbon strategy and renewable electricity storage. This research reviews the current state-of-the-art advancements in the coelectrolysis of CO2/H2O in solid oxide electrolyzer cells (SOECs) to produce the important syngas intermediate. The overviews of the latest research on the operating principles and thermodynamic and kinetic models are included for both oxygen-ion- and proton-conducting SOECs. The advanced materials that have recently been developed for both types of SOECs are summarized. It later elucidates the necessity and possibility of regulating the syngas ratios (H2:CO) via changing the operating conditions, including temperature, inlet gas composition, flow rate, applied voltage or current, and pressure. In addition, the sustainability and widespread application of SOEC technology for the conversion of syngas is highlighted. Finally, the challenges and the future research directions in this field are addressed. This review will appeal to scientists working on renewable-energy-conversion technologies, CO2 utilization, and SOEC applications. The implementation of the technologies introduced in this review offers solutions to climate change and renewable-power-storage problems.

Fatigue Testing Approach Utilising Machining Cutting Forces and Fixture Design

Abstract Background Traditional fatigue testing methods can be expensive due to the need of specialised equipment for engineering materials and structures. Thus, a new fatigue testing approach utilising machining cutting forces to induce cyclic stresses, enabling fatigue life assessment of engineering materials and structures, has been developed. Objective This research aims to develop and verify a new testing approach using machining processes to enable the fatigue life assessment of engineering materials and structures. This is achieved by the utilisation of machining-induced cutting forces to generate cyclic stresses into welded samples used in applications of wind turbine monopile structures. Methods The methodology employes the development of a fixture encompassed with strain gauges and purposefully designed machining operations to mimic the cyclic stresses experienced in real applications. The machining-based fatigue testing approach was demonstrated on welded samples by replicating cyclic stresses of offshore wind turbine monopiles subject to in-service loads. Results The results show that rapid fatigue testing of engineering materials and structures is possible by utilising existing machine tools and centres, which are widely accessible to industry. Cyclic stresses were induced in welded structural steel samples proving the concept of this method. Conclusion This novel fatigue testing method showed that cyclic stresses can be induced by machining cutting forces to address real application needs. The key advantages are that this method can be quickly set up in industry, enabling fast fatigue testing that can lead to reduction of lead times for product and process development of industrial components.

Intestinal Coccidia (Eimeriidae, Coccidia) of Synanthrophic Animals of the Urban Population

Intracellular parasitic protozoa (Protozoa) have been found in many vertebrates inhabiting various natural regions of the Earth. Numerous parasitic protozoa have been found in vertebrates in Azerbaijan, including representatives of the eimeriid coccidia (Eimeriorina: Coccidia: Apicomplexa, Protozoa). Among them, representatives of the genera Cryptosporidium(zoonoses) and Eimeria (highly specific) have the greatest practical significance in animal husbandry and medicine. Synanthropes, especially inhabitants of the urbanized ecosystem, are in contact with domestic animals and humans, which contributes to the exchange of ecto- and endoparasites between them. The article presents the results of studies of coccidia infection of synanthropic animals in Baku and its environs. And an attempt was made to find out whether wild animals are reservoirs of opportunistic pathogens. The research material was oocysts of eimeriid coccidia found in the faeces of synanthropic animals. Fecal samples of the studied animals were collected in their habitats. A total of 286 fecal samples from 6 species of animals were examined: 72 birds (12 European herring gulls and 60 rock doves), 161 rodents (54 brown rats and 107 house mice), domestic dogs and cats — 25 and 28, respectively. All studied animals were infected with cryptosporidium. Eimeria oocysts were found only in rodents and one rock dove. Based on morphometric parameters, it can be argued that the cryptosporidium oocysts found in mammals are C. parvum-like and C. muris-like, in rock doves C. parvum-like, C. galli-like. Single cryptosporidium oocysts found in gulls were not diagnosed. Eimeria oocysts found from rats match E. miyairii in morphometric characteristics, and two different types of Eimeria oocysts — Eimeria sp. 1 and Eimeria sp. 2 are supposed to be new species. Eimeria oocysts found by us in mice correspond in their size and morphology to E. krijgsmanni.

Air Pollution as a Problem of the Modern World

Research relevance: the development of diseases and pathological conditions caused by air pollution depends on the types of pollutants, their physical and chemical characteristics, while air pollution increases the incidence of respiratory diseases. Research objectives: to develop a scheme for the pathogenesis of the development of immunological disorders in the body of people living in conditions of exposure to atmospheric air pollutants, to conduct a statistical analysis of factors influencing the development of allergic rhinitis and the development of bronchial asthma. Research materials and methods: a study of the characteristics of atmospheric air was carried out in three places in Kyrgyzstan: in the area of ​​the village Papan, near the village Gulbar, and Aravan district and near the Osh city. The study was an open, prospective, non-interventional, observational study in parallel groups. The study participants included residents of three regions of the Kyrgyz Republic, depending on the degree of air pollution. Research results: the data obtained indicated that people living in different regions of the Kyrgyz Republic with varying degrees of atmospheric pollution exhibit significant differences in indicators indicating pathology of the upper respiratory tract and allergization of the body. Conclusions: The harmful effects of air pollution and climate change on human health can be largely prevented through the timely adoption of the necessary legislation.

A comprehensive study of melt foaming in E‐glass batch‐to‐melt conversion process: Effects of sulfate content and chemistry of raw materials

AbstractControl of sulfate‐induced melt fining without excessive foaming is one of the critical steps in maintaining the stability of E‐glass fiber manufacturing processes. Besides, the efficiency of combustion or energy utilization is directly affected by the extent of the melt‐foaming. A fundamental understanding of key factors affecting melt foaming under the simulated oxy‐fuel combustion environment will enable commercial E‐glass fiber production to optimize both batch chemistry and operation conditions to achieve adequate furnace control. In this study, six types of E‐glass batches with the same target glass composition were prepared by using four different CaO sources; calcined limes with different SO3 contents, limestone, limestone with sodium sulfate, and a mixture of limestone and calcined lime. All batch samples were examined by HTMOS‐EGA system (high temperature melting observation system with evolved gas analysis). HTMOS enables monitoring batch‐to‐melt conversation steps by using a high‐resolution camera and EGA detects the evolved reaction gaseous, such as CO, CO2, and SO2 via an Fourier transform infrared (FTIR) gas analyzer. Gases of water vapor, N2, and O2 were introduced accordingly into the fused quartz crucible to simulate similar oxy‐fuel atmosphere of the furnace operation. This study aimed to investigate the effects of different SO3 contents in batches and different raw material chemistries on the foam formation in E‐glass melts under the oxy‐fuel atmosphere. Different raw materials were characterized by mineralogical analysis, chemical analysis, particle size distribution, chemical oxygen demanding (COD) level, and Brunauer–Emmett–Teller (BET) analysis. Although some of the batches contained the same SO3 content, different foam formations resulted from the effect of the batch chemistry. Our detailed HTMOS‐EGA investigations show that not only SO3 content in the batch affects foam formation in E‐glass melts, but also raw material chemistry and particle size have strong effects on the melt foaming in E‐glass batch melting, especially for those of ingredients having hydroxide phases and/or finer particles with higher specific areas.

Vibrational properties of disordered stealthy hyperuniform 1D atomic chains

Disorder hyperuniformity is a recently discovered exotic state of many-body systems that possess a hidden order in between that of a perfect crystal and a completely disordered system. Recently, this novel disordered state has been observed in a number of quantum materials including amorphous 2D graphene and silica, which are endowed with unexpected electronic transport properties. Here, we numerically investigate 1D atomic chain models, including perfect crystalline, disordered stealthy hyperuniform (SHU) as well as randomly perturbed atom packing configurations to obtain a quantitative understanding of how the unique SHU disorder affects the vibrational properties of these low-dimensional materials. We find that the disordered SHU chains possess lower cohesive energies compared to the randomly perturbed chains, implying their potential reliability in experiments. Our inverse partition ratio (IPR) calculations indicate that the SHU chains can support fully delocalized states just like perfect crystalline chains over a wide range of frequencies, i.e. ω∈(0,100) cm−1, suggesting superior phonon transport behaviors within these frequencies, which was traditionally considered impossible in disordered systems. Interestingly, we observe the emergence of a group of highly localized states associated with ω∼200 cm−1, which is characterized by a significant peak in the IPR and a peak in phonon density of states at the corresponding frequency, and is potentially useful for decoupling electron and phonon degrees of freedom. These unique properties of disordered SHU chains have implications in the design and engineering of novel quantum materials for thermal and phononic applications.

Photoswitching Reagent for Super-resolution Fluorescence Microscopy.

Single-molecule localization microscopy (SMLM) has revolutionized optical microscopy by exceeding the diffraction limit and revealing previously unattainable nanoscale details of cellular structures and molecular dynamics. This super-resolution imaging capability relies on fluorophore photoswitching, which is crucial for optimizing the imaging conditions and accurately determining the fluorophore positions. To understand the general on and off photoswitching mechanisms of single dye molecules, various photoswitching reagents were evaluated. Systematic measurement of the single-molecule-level fluorescence on and off rates (kon and koff) in the presence of various photoswitching reagents and theoretical calculation of the structure of the photoswitching reagent-fluorophore pair indicated that the switch-off mechanism is mainly determined by the nucleophilicity of the photoswitching reagent, and the switch-on mechanism is a two-photon-induced dissociation process, which is related to the power of the illuminating laser and bond dissociation energy of this pair. This study contributes to a broader understanding of the molecular photoswitching mechanism in SMLM imaging and provides a basis for designing improved photoswitching reagents with potential applications extending to materials science and chemistry.

Plastic Waste Valorization: Prospects for Green Hydrogen Production

Abstract: Plastic waste is a current issue worldwide that is already negatively influencing and threatening the lives of human beings, with residual micro- and nanoplastics entering water and soil bodies inducing recalcitrant pollution and health issues. The proposed perspective has been aimed to provide an overview of the potential of plastic waste valorization to green hydrogen and carbonaceous nanostructures. The overall concept additionally includes the utilization of the generated carbonaceous nanostructures to design advanced functional materials in combination with the obtained green hydrogen from plastic waste in a number of batch-to-flow catalytic hydrogenations to close the circle of sustainable integrated valorization of plastic waste. The concept also includes insightful Life-Cycle Assessment (LCA) and techno-economic studies in order to select the most relevant lines from the sustainability and cost-competitive standpoints.

Three-Step Ferroelastic Transitions from Hexagonal to Triclinic Phases in a Hybrid Perovskite: (1-Fluoromethyl-1-methylpyrrolidine)[CdCl3].

Hybrid ferroelastic crystals have emerged as a hot research topic in recent years owing to their prospective applications in piezoelectric sensors, mechanical switches, and optoelectronic devices. Nevertheless, most of the documented materials exhibit one-step or two-step ferroelastic phase transition(s), and those with multistep ferroelastic transitions are extremely scarce. We present a new hexagonal molecular perovskite based on a fluoro-substituted flexible cyclic ammonium cation, (1-fluoromethyl-1-methylpyrrolidine)[CdCl3] (1), undergoing unusual three-step ferroelastic phase transitions from hexagonal paraelastic phase to orthorhombic, monoclinic, and triclinic ferroelastic phases at 388, 376, and 311 K, respectively, with Aizu notation of 6/mmmFmmm, mmmF2/m, and 2/mF-1, featuring spontaneous strain of 0.002, 0.023, and 0.110, respectively. Furthermore, variable-temperature single-crystal diffraction reveals that the phase-transition mechanism in 1 principally originates from intriguing dynamic change of organic cations and synchronous displacement of inorganic chains. This scarce instance of multistep hybrid ferroelastic provides important clues for finding advanced ferroelastic materials.

A Study on The Problematization of Logistics in Agricultural Production in The State of Tocantins

Objective: the research aims to describe the logistical service system, observing the problematization of agricultural production in the state of Tocantins, considering that this sector is one of the most promising in terms of socioeconomic and regional development in the country.
  
 Theoretical benchmark: with the growing advancement of agricultural production and the exploration of new frontiers, Brazil stands out as one of the main exporters of agricultural products today. Given the significant development of agriculture, it is observed that the logistical factor, mainly costs and infrastructure, is among the elements with the greatest impact on the efficiency of the entire agricultural production chain in the state of Tocantins.
  
 Method: the methodology adopted will be the deductive method, based on theoretical logistics studies, applicable legislation, and support materials for logistics learning systems, in addition to economic representation in the state of Tocantins. The resources used include bibliographic and documentary material and other instruments or research techniques in accordance with the adopted methodology, aiming to provide support for research on the proposed theme.
  
 Results and conclusion: given the content of this study, it is highlighted that the chain of agricultural processes encompasses a complex network of activities in the production chain, and cannot be conceived solely as a relationship between producer and consumer, given its breadth of action. In this context, it should be noted that logistics services end up representing one of the obstacles to the development of agriculture in the State of Tocantins, mainly due to its geographic location.
  
 Implications of the research: the approach adopted in this research offers unprecedented scientific contributions to the field of logistics, providing theoretical bases for interventions and public policies that can impact this economic activity in a Brazilian state with strong economic and social growth trends, whose production has repercussions at national and international levels.
  
 Originality/value: the social transformations of recent decades, related to the process of globalization of the economy and technology, have directly influenced the social and economic life of countries, affecting production and service chains and interfering in labor relations. Therefore, the increase in regions dedicated to agribusiness activities is a general trend among emerging countries, requiring a deeper understanding of the territorial approach to regional development, especially in economic activities hampered by bottlenecks in the logistics system, both national and international. Thus, new reflections and planning are necessary and imperative elements in Brazilian states like Tocantins.